Application notes

Coating a difficult active

Notes on specific actives. What the core does, which grades handle it, the order they go on in, and the failure to expect on a first batch.

1 note

Pantoprazole sodium
Coating the Pantoprazole group
Pantoprazole is acid labile. It degrades in stomach acid, so the tablet has to reach the intestine intact. It is also sensitive to the enteric polymer itself, which means an enteric film applied straight onto the core creates its own problem while solving another.
SC-401ECM-RP347

Notes are added as products come through our trials, so this list grows rather than arriving complete. If you are coating something that fights back, send us the core and the symptom and the answer we work out becomes the next note.

Coated on our own pan

Metallic gold film coat
Metallic blue DB3012
Aqueous colour film coat
Extra white film coat

Coating a difficult active

1 note

Coating the Pantoprazole group