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Rglax Pharma

Dissolution Profile Material

A blend added at the compression stage to correct disintegration time and dissolution where the core alone falls short.

What this range covers

Dissolution enhancer blends used to correct disintegration time and dissolution profiles where the core formulation on its own does not meet specification.

Range

Grades held
1
Process base
Dry blend
Brand
Rglax Coat
Made at
Tahliwal, Distt. Una, H.P.
Enhancer through the coreAdded at the blending stageTablet coreNo coat appliedCross-section, not to scale
The enhancer is distributed through the core before compression, which is why disintegration and dissolution are run before and after addition on the same core.

Common questions

When the core does not meet the specified disintegration time or dissolution profile and reformulating the core is not practical. It is added at the blending stage rather than applied as a coat.

Run disintegration and dissolution before and after addition on the same core. That separates the effect of the blend from ordinary batch to batch variation.

It is used where reformulating is not practical. If the core has a deeper problem than disintegration time, the blend corrects the symptom rather than the cause, and reformulation is still the better answer.

No. It goes in at the blending stage, alongside RT-114, HR100 and SR100. None of the four are sprayed, so there are no coating parameters to set for them.
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